Chemistry lessons

Helen Hunt

TV hit: “Mad About You” (1992-1999)

Rom-com debut: “As Good As It Gets” (1997)

Hot or not: Hot. Hunt managed to click with cranky Jack Nicholson in a hit movie and became a rare actress to win an Oscar while also starring in a weekly series. She followed it up with “What Women Want,” one of the highest grossing romantic comedies of all time.

Up next: After only a handful of screen appearances in the last few years Hunt will star in her directorial debut “Then She Found Me” alongside Colin Firth, Matthew Broderick and Bette Midler.